If you are looking for a non-GLP-1, physiology-friendly way to support fat loss around the waist, protect lean muscle, and improve post-workout recovery, you may be a candidate for our bedtime peptide combo: tesamorelin + ipamorelin.

Below is a clear, patient-friendly overview of what the combo does, who it may help, how it is used, and what to expect.

What it is

  • Tesamorelin is a growth-hormone–releasing hormone analog. It tells your pituitary to make your own growth hormone GH.

  • Ipamorelin is a gentle GH secretagogue ghrelin mimetic. It helps the pituitary release that GH signal without spiking cortisol or prolactin.

Taken at bedtime, together they amplify your body’s natural GH pulse that occurs in deep sleep. This is not an anabolic steroid and not a crash diet. It is a way to restore a physiologic repair signal so that your efforts with nutrition, resistance training, and sleep produce better results.

What it can help

  1. Visceral belly fat
    Tesamorelin has FDA approval to reduce deep abdominal fat in one setting HIV-associated lipodystrophy. Outside that setting we use it off-label in selected adults with stubborn waist fat. Many patients notice a looser waistband and better metabolic markers over time.

  2. Lean-mass protection and recovery
    In periods of reduced activity, surgery, illness, or weight loss, it is easy to lose muscle. A stronger bedtime GH pulse supports muscle protein synthesis, connective-tissue remodeling, and faster bounce-back from training or physical therapy.

  3. Sleep and next-day energy
    People often report deeper slow-wave sleep and clearer morning energy. Better sleep amplifies the benefits of exercise and healthy nutrition.

Who may be a good candidate

  • Waist-focused fat gain despite steady effort

  • Muscle loss or slow rehab after injury or surgery

  • Tired or sore after workouts longer than expected

  • You prefer a non-GLP-1 option or did not tolerate GLP-1s

Not ideal if you have active cancer, uncontrolled diabetes, proliferative retinopathy, or if you are pregnant or breastfeeding.

How it is taken

  • Timing: Inject 30–90 minutes before lights out, at least 2–3 hours after your last calories. Avoid late snacks and alcohol those blunt the GH response.

  • Where: Tiny subcutaneous shots into the fatty layer of the lower abdomen, outer thigh, or back of the upper arm. Rotate sites. Use clean technique and a fresh insulin syringe each time.

  • Storage: Refrigerate per pharmacy instructions.

What to pair with it for best results

  • Protein first: Aim for 1.6–2.0 g per kg body weight per day roughly 25–40 g per meal.

  • Resistance training: 2–3 short sessions per week push, pull, legs, core using pain-guided progressions.

  • Daily steps and post-meal walks: 10–20 minutes after lunch or dinner reduces glucose and fat spikes.

  • Fiber: At least 30 g per day vegetables, beans or lentils, chia or ground flax; add a gentle soluble fiber if needed.

  • Sleep window: Protect 7–8 hours with consistent bed and wake times.

The combo enhances a good plan it does not replace it. If nutrition, training, and sleep are not in place, results will be limited.

What to expect

  • Weeks 1–2: Many notice deeper sleep and less next-day soreness after training or PT.

  • Weeks 3–6: Easier progress in the gym and a tighter waist, even if the scale changes slowly muscle is denser than fat.

  • Weeks 6–12: Clearer body-composition improvements and better stamina when protein and training are steady.

Everyone’s timeline is different. We rely on your weekly metrics to guide adjustments.